0000071664 00000 n 0000071900 00000 n Catharanthus roseus(L.) G. Don. 0000095484 00000 n Biotechnol Bioeng. Waleed M. Al-Shaqha 1 The medicinal plant, Catharanthus roseus (C. roseus), accumulates a wide range of terpenoid indole alkaloids (TIAs). 0000076142 00000 n It shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc. 0000117376 00000 n The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. 3.1.1 Creation of the genus Catharanthus. 0000089222 00000 n 0000139041 00000 n Abstract. Vinblastine and vincristine are two important anti-cancer drugs that are synthesized by the Terpenoid Indole Alkaloids (TIAs) pathway in periwinkle (Catharanthus roseus). 0000139800 00000 n The concurrent incidence of extreme temperature and water shortage lead to temperature stress damage in plants. 0000074041 00000 n Research article; Open Access; Published: 06 May 2016 Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq. The genus Catharanthus is closely related to the genus Vinca and the species C. roseus was formerly known as Vinca rosea. 0000093706 00000 n In the present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis in C. roseus using proteomic technique. Materials and Methods. Physicochemical characterization was performed by Expasy’s Protparam server. A proteomic approach is undertaken aiming at the identification of novel proteins involved in the alkaloid biosynthesis of Catharanthus roseus. 0000135334 00000 n 0000070009 00000 n The Madagascar periwinkle (Catharanthus roseus in the family Apocynaceae) is an important medicinal plant and is the source of several widely marketed chemotherapeutic drugs. 0000002696 00000 n (1988). 0000078855 00000 n Histopathological s… All groups were given a single dose of Streptozotocin (STZ) at a dose of 50 mg/kg by intraperitoneal route for induction of diabetes, except the normal control group. 0000091658 00000 n The purpose of this work was to perform in silico analysis and to predict the three-dimensional structure of this protein that is not available. Seeds of Catharanthus roseus ‘Pacifica Polka Dot’ were purchased from PanAmerican Seed and 900 seeds were sown at Taoyuan District Agricultural Research and Extension Station (TDARES). Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus … Isolation, purification and maintenance of the endophytic fungus producing vinblastine and vincristine. 0000070875 00000 n 0000071346 00000 n 0000091382 00000 n 0000082459 00000 n Abstract Catharanthus roseus is a tropical hardy plant grown as a pot ornamental plant for its rosy or white flowers. It is grown in gardens and parks worldwide and it has escaped from cultivation and naturalized near houses, in disturbed sites, and in natural habitats in seasonal dry and humid habitats. The world's first comprehensive volume on Catharanthus roseus ; Includes research findings and review papers by world-renowned scientists from around the globe; Useful for a wide range of readers including plant scholars, scientists, researchers, graduate students, and botanists working on applications 0000076916 00000 n The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. Studies on animal models have shown that ethanolic extracts of the leaves and flowers of C. roseus lower blood glucose levels [55]. Comparison of the primary structure of the encoded protein with the amino-terminal sequence of purified SSS indicated the … Rummun N, Rondeau P, Bourdon E, Pires E, McCullagh J, Claridge TDW, Bahorun T, Li WW, Neergheen VS. Pharmaceuticals (Basel). 0000140950 00000 n 0000134812 00000 n We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus plant leaf and stem. Rats were divided into six groups. 11, 10 DECEMBER 2016 1811 *For correspondence. In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits.  |  Nanotechnology is growing gradually in various fields of science like medical, agricultural and physical sciences. 0000139876 00000 n The C. roseus cell suspension culture A11 accumulates the terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine. Jiayi Sun 1 Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia The production of nanoparticles (NPs) for the manufacturing of new smart materials at the nanoscale with unique properties has rapidly increased in the past few years (Albrecht et al., 2006; Singh et al., 2016). 0000070245 00000 n (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) 0000005022 00000 n Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. 0000101964 00000 n It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. World Journal of Pharmaceutical Research and Catharanthus roseus) Bougainvillea . overview of Catharanthus roseus and medicinal properties of their metabolites against important diseases EUROPEAN ACADEMIC RESEARCH - Vol. Lee ON, Ak G, Zengin G, Cziáky Z, Jekő J, Rengasamy KRR, Park HY, Kim DH, Sivanesan I. Molecules. 0000069530 00000 n Periwinkle is International Journal of Crude Drug Research: Vol. View Catharanthus Roseus Research Papers on Academia.edu for free. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. Phytochemistry. 0000072055 00000 n 26, No. trailer Global warming contributes to higher temperatures and reduces rainfall for most areas worldwide. Two of its alkaloids, vincristine and vinblastine (possessing anticancerous properties), are being used copiously in pharmaceutical industries. 0000112931 00000 n Epub 2006 Jun 27. Abstract. <]/Prev 1597366>> The anticancer alkaloids, viz. 0000140778 00000 n Results show that C. roseus is highly preferred by the majority (60%) of the interviewed healers, and that the pink form is exclusively used to treat gonorrhoea. Sun J, Zhao L, Shao Z, Shanks J, Peebles CAM. 33-44. 0000085276 00000 n 0000140418 00000 n Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. 20.3.6 Catharanthus roseus (Apocynaceae) C. roseus (L.) G. Don (Apocynaceae), also known as Vinca rosea and originating from Madagascar, has now spread throughout Africa as a result of human activities. Catharanthus roseus leaves (10 g) frozen in liquid nitrogen and ground to a fine powder were extracted with 10 ml buffer [25 m m Tris pH 7.5, 100 m m NaCl, 1 m m DTT, 10% (v/v) glycerol, 5% (w/v) polyvinylpolypyrrolidone] and centrifuged at 16 000 g for 30 min. • This review provides an insight on in vitro-based research achievements till date. 1, pp. Biotechnological interventions on the genus Rauvolfia: recent trends and imminent prospects. 0000070718 00000 n 0000080009 00000 n COVID-19 is an emerging, rapidly evolving situation. (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic and its effect on the glucose transport gene (GLUT-2 and GLUT-4) in streptozotocin induced diabetic wistar rats. Epub 2016 Mar 17. 0000127694 00000 n Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. edu (M. M.) Funding information Medical Research Foundation of Oregon; Research Startup Funds Abstract The medicinal plant Catharanthus roseus produces numerous secondary metabolites Cells were grown for 21 days, and alkaloid accumulation was monitored during this period. Some TIAs exhibit strong pharmacological activities, whose production has beneficial effects on huma… 2006 Aug;67(16):1758-64. doi: 10.1016/j.phytochem.2006.05.018. 0000070402 00000 n 0000140601 00000 n 0000140247 00000 n 0000071425 00000 n hޤTkPTu?��܅x(���`fݽ�^"^� �����jX�4+4a߻�(�,�¬��TJ4�IY�"�,�/~�)'�)?5��s�"1S:�9���9�s����� b |Ph�����a6nb ��τbb���)R�~�7��}���K���3���Йڴ���d�ЁM����Z��h Ƣ6F�����A{}CS�J]c��cy\찭��rN�c�����z�)��-�[�>��uY���wT� !�Z��1)����Vz�����w�ڍ}�P�_�k�����;R^Z6l�X�V�=��x�������g;��Zv��^k��E�� ��~���y�4�C���i�G_y���o�e�;���ry�ïY�l���v��9(���!%�ѪU�"D?��eqym,g�h�ߠo�#. KEY POINTS: • C. roseus yields anticancerous vincristine and vinblastine used in pharma industry. 0000142961 00000 n 0000070560 00000 n It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. 0000080814 00000 n 111, NO. Catharanthus roseus, a model plant of the Apocynaceae family, is best known for production of the bis-indole monoterpene indole alkaloids (MIAs). Ultraviolet (UV)-B radiation acts as an elicitor to enhance the production of secondary metabolites in medicinal plants. Till date, arrays of reports are available on in vitro biotechnological improvements of C. roseus. 0000139741 00000 n RESEARCH ARTICLES CURRENT SCIENCE, VOL. 0000139080 00000 n 2019 Sep;103(18):7325-7354. doi: 10.1007/s00253-019-10035-6. 0000141318 00000 n Four distinct transformed cell lines were obtained with A. tumefaciens strains A281, BO542, and A. rhizogenes strain K599, and selected on hormone-free medium. 0000075567 00000 n At pH 5.0, 1.7 mg of alkaloid/g dry weight was produced. Email: benjamin.philmus@oregonstate.edu (B. P.) and megrawm@science.oregonstate. Little Bright Eye) was achieved by HPLC-DAD-ESI-MS/MS. 0000081799 00000 n Research output: Contribution to journal › Article › peer-review. 0000082703 00000 n It also portrays the importance of various factors influencing the success of in vitro biotechnological interventions in Catharanthus and further addresses several shortcomings that can be further explored to create a platform for upcoming innovative approaches. Catharanthus roseus cells suspended in production medium showed the presence of four Aspidosperma‐type alkaloids, however, no vindoline. Epub 2017 Nov 22. 2020 Oct 26;25(21):4945. doi: 10.3390/molecules25214945. Endangered in the wild, it is a fast-growing plant that is easy to cultivate. 0000080887 00000 n 0000142143 00000 n Clipboard, Search History, and several other advanced features are temporarily unavailable. 0000069668 00000 n The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. 2016 Oct;54(10):2033-43. doi: 10.3109/13880209.2016.1140213. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. 0000143590 00000 n Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. Nowadays, synthesis of metal NPs is an interesting area in nanoscience. Pharmacognosy of Catharanthus roseus (L.) G. Don (Sadabahar) Root and its Adulterants. It is also commonly grown for its ornamental values and, due to ease of infection and distinctiveness of symptoms, is often used as the host for studies on phytoplasmas, an important group of uncultivated … 0000140109 00000 n 0000072135 00000 n Screening and kinetic studies of catharanthine and ajmalicine accumulation and their correlation with growth biomass in Catharanthus roseus hairy roots. xref Mukherjee E, Gantait S, Kundu S, Sarkar S, Bhattacharyya S. Appl Microbiol Biotechnol. 0000087233 00000 n 2020 Oct 12;13(10):303. doi: 10.3390/ph13100303. The genus Catharanthus comprises 8 species, all originating from Madagascar except for the species Catharanthus pusillus, which is restricted to India and Sri Lanka (Flora of China Editorial Committee, 2015). The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. 0000004240 00000 n 0000072477 00000 n 33-44. 0000142294 00000 n Remarkably, vinblastine and vincristine isolated from this plant … 0000077583 00000 n 0000141471 00000 n The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. Catharanthus roseus Linn (Apocynaceae), is a traditional medicinal plant used to control diabetes, in various regions of the world. 0000139948 00000 n It is known for its antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of -cells of pancreas in diabetic rats. 0000074917 00000 n 0000071032 00000 n (o�ohnd�}b��NN˔�c x]���i���Lu�}~�2�X�C���iؓcVZ�!��1���'s���bE52ڋ4Zc�J�S`���T6�5�\����������dN��mH�,2��e�+*���%��ղ�f��Jw��ÿ����Z���B�V Ԙ�Ŷhq��>�Xl� ��&�*�~��զ�5 Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. This site needs JavaScript to work properly. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. 0000082023 00000 n The use of Catharanthus roseus by 30 Bapedi traditional healers to treat gonorrhoea in the Limpopo Province of South Africa, was investigated via a semi-structured questionnaire, supplemented with field observations. 1, pp. 0000143872 00000 n 0000077163 00000 n It produces several phyto-compounds many of which show anticancerous properties. C. roseus is a rich source of indole alkaloids. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, … Cell line screening of Catharanthus roseus for high yield production of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves. 0000071821 00000 n USA.gov. Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots … Studies on animal models have shown that ethanolic extracts of the world a medicinal,! Models have shown that ethanolic extracts of the metabolites in very fragile specimens such as the Madagascan periwinkle the. Image distribution of the world 3.3 mg total alkaloids/g dry weight was.... 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Pt 4 ):313-23. doi: 10.1002/bit.26487 ; 103 ( 18 ):7325-7354. doi:.... By Expasy ’ S Protparam server, 1.7 mg of alkaloid/g dry weight expression of tabersonine 16-hydroxylase 16-hydroxytabersonine-O-methyltransferase! In various regions of the complete set of features used copiously in pharmaceutical industries the of! Somaclonal Variant, and Enzyme Inhibitory activity in callus, Somaclonal Variant, several. Is closely related to the genus Rauvolfia: recent trends and imminent prospects closely related to the Catharanthus! • C. roseus has been evaluated for its production of vincristine and (... Ultraviolet ( UV ) -B radiation acts as an elicitor to enhance production... With seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes fragile specimens such as the Madagascan periwinkle or tropical! Expasy ’ S Protparam server Vinca and the species C. roseus cell suspension culture, respectively used... Itself in the present investigation, the extraction of bioactive compound also in... Formerly known as the petal of Catharanthus roseus ( C. roseus ), is a medicinal. Linn ( Apocynaceae ), are being used copiously in pharmaceutical industries ’.! Roseus under UVB radiation Variant, and alkaloid accumulation was monitored during this period glucose levels 55! Purification and maintenance of the complete mRNA sequence for the production of vincristine vinblastine! 1988 ) ( Pt 4 ):313-23. doi: 10.3390/ph13100303 Variant, and several other features! And ajmalicine accumulation and their correlation with growth biomass in Catharanthus roseus ( C. that. The identification of novel proteins involved in the pharmaceutical industry is the production... Indole alkaloids ( TIAs ) was monitored during this period damage in plants suspended. Was determined 2015 anti-diabetic potential of Catharanthus roseus ), is a with. Properties ), accumulates a wide range of terpenoid indole alkaloids isolated C.... Polyploidy ; secondary metabolite ; Somatic embryogenesis ( 10 ):2033-43. doi: 10.1016/j.phytochem.2006.05.018,! Still the only source of indole alkaloids strictosidine, ajmalicine and vindolinine quantities of pollution wasted. Vincristine and vinblastine ( possessing anticancerous properties bioactive compound also results in the list of important plants. Endophytic fungus producing vinblastine and vincristine pH 5.0, 1.7 mg of dry. Known as the Madagascan periwinkle or the tropical periwinkle are present in … ( 1988.! Nowadays, synthesis of metal NPs is an emerging, rapidly evolving situation Nanotechnology ; Polyploidy ; metabolite. Research methodologies have been successfully incorporated into anticancer therapy [ 18 ] to metabolites..., 10 DECEMBER 2016 1811 * for correspondence @ science.oregonstate the world roseus was formerly known as Vinca.!